Showing posts with label Breast Cancer. Show all posts
Showing posts with label Breast Cancer. Show all posts

Monday, 24 September 2012

Ovarian Cancer Patients-European Union Group-Swiss Drug Maker-European Panel

European panel recommends Avastin for type of ovarian cancer patients

Avastin, the world's best-selling cancer drug from Swiss drug maker Roche, received a positive opinion Friday from a European Union group to treat a subset of ovarian cancer patients.The Committee for Medicinal Products for Human Use, or CHMP, essentially recommended that EU authorities approve Avastin in combination with the chemotherapy agents carboplatin and gemcitabine to treat women with recurrent, platinum-sensitive ovarian cancer, the company said Friday.Avastin was developed by South… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)MedWorm Sponsor Message: Please have a look at this new site driven by MedWorm: The Breast Cancer Daily read more..

Tuesday, 28 August 2012

Breast Cancer Recurrence-Risk

Excess Pounds Raise Risk of Breast Cancer Recurrence, Death: Study

MONDAY, Aug. 27 -- Women who are overweight or obese when diagnosed with the most common form of breast cancer have a higher risk of recurrence than slimmer patients, according to a new analysis."Patients who are obese are significantly more... read more..

Tuesday, 14 August 2012

Study Questions Guidelines-Radiation Treatment-Physical Activity-Breast Cancer-Brisk Walking

Study Questions Guidelines on Radiation for Older Breast Cancer Patients

MONDAY, Aug. 13 -- Giving radiation treatment to older women with early-stage breast cancer who have undergone a lumpectomy could lower their risk of needing a mastectomy later on, new research shows.This suggests that current guidelines... read more..


More Evidence That Exercise in Middle Age Boosts Health

MONDAY, Aug. 13 -- Keeping up a leisure-time physical activity regimen for a decade or more could help middle-aged adults improve their heart health, researchers report.Over time, routine activities -- such as brisk walking, biking, or even doing... read more..

Saturday, 21 July 2012

Pennsylvania Superior Court-Pennsylvania Supreme Court-Compensatory Damages-Punitive Damages

Pay up Pfizer

Pfizer Must Pay $10.4 Million In Prempro Lawsuit, Court Rules
Pfizer Inc. must pay $10.4 million in damages to a woman who blamed the company’s Prempro menopause drug for her breast cancer, an appeals court said.
Jurors properly awarded Audrey Singleton, who sued Pfizer’s Wyeth unit over Prempro, compensatory and punitive damages over the company’s marketing of the drug, the Pennsylvania Superior Court ruled yesterday. Singleton’s lawyers alleged that Wyeth hid the drug’s health risks and a jury awarded her damages on those claims in 2010.
“Wyeth’s concerted effort to misdirect physicians from the dangers of Prempro illustrates the consciousness that its conduct was not at all reasonable,” the three-judge panel said in upholding the jury’s findings.
More than 6 million women took Prempro and related menopause drugs to treat symptoms including hot flashes and mood swings before a 2002 study highlighted their links to cancer. At one point, Pfizer (PFE) and its units faced more than 10,000 lawsuits over the medications.
Until 1995, many patients combined Premarin, Wyeth’s estrogen-based drug, with progestin-laden Provera, made by Pfizer’s Pharmacia & Upjohn unit. Wyeth combined the two hormones in Prempro. The drugs are still on the market.
Chris Loder, a spokesman for New York-based Pfizer, couldn’t immediately comment yesteday on whether the drugmaker would ask the Pennsylvania Supreme Court to review the award to Singleton.
‘Deliberate Disregard’
Esther Berezofsky, one of Singleton’s lawyers, said she was pleased the intermediate appellate court backed the jury’s finding that Wyeth officials misled patients and doctors about Prempro’s risks.
“The court affirmed that the evidence established Wyeth’s conscious and deliberate disregard for the cancer risk associated with Prempro,” Berezofsky said in an e-mailed statement.
The ruling comes as Pfizer officials are working to settle lawsuits over the menopause drugs. The drugmaker has now settled about 60 percent of the cases over the medicines and paid out $896 million, executives said in May in a filing with the U.S. Securities and Exchange Commission. The company has set aside an additional $330 million to resolve the remaining cases, according to the filing.
Singleton, a mother of three from Alabama, began taking Prempro in August 1997, according to court filings. The results of a mammogram at that time were normal, her lawyers said during the trial. She stopped taking the drug in January 2004 after her breast cancer diagnosis.
She sued Wyeth, later acquired by Pfizer, in state court in Pennsylvania where the company has extensive operations. A Philadelphia jury awarded her $3.4 million in compensatory damages and $6 million in punitive damages in February 2010. The judge in the case later added almost $1 million in interest to the verdict.
The appellate panel found Singleton’s lawyers presented enough evidence that Wyeth officials downplayed or hid Prempro’s health risks to justify the compensatory award.
Jurors also properly weighed whether Wyeth should be held liable for punitive damages and reasonably concluded “Wyeth’s actions were not justifiable,” the judges said in a 30-page decision.
“There is nothing in the record that illustrates the $6 million punitive damages award was grossly excessively as to shock our sense of justice,” the panel wrote.
The case is Singleton v. Wyeth Inc., 050102885, Court of Common Pleas, Philadelphia County, Pennsylvania (Philadelphia).
To contact the reporter on this story: Jef Feeley in Philadelphia at jfeeley@bloomberg.net.
To contact the editor responsible for this story: Michael Hytha at mhytha@bloomberg.net
http://www.bloomberg.com/news/2012-07-21/pfizer-must-pay-10-4-million-in-prempro-lawsuit-court-rules.html? read more..

Friday, 20 July 2012

Breast Cancer Treatment-Postmenopausal Women-British Researchers-Obesity

Obesity Might Hinder Treatment of Some Breast Cancers

MONDAY, July 16 -- Being obese may affect a woman's response to breast cancer treatment, a small new study suggests.British researchers looked at 54 postmenopausal women with estrogen receptor-positive breast cancer, meaning that the tumor may... read more..

Thursday, 19 July 2012

Alzheimer&Amp;#39;S Disease-Infant Birth Weight-Birth Defects-Breast Cancer-Men And Women

Study Ties Infant Birth Weight to Mothers' Breast Cancer Risk

TUESDAY, July 17 -- Women who give birth to large infants may have a more than twofold increased risk of developing breast cancer, according to a new study.Having a large baby may be associated with higher concentrations of certain pregnancy... read more..


Can a Parent's Job Raise Odds for Birth Defects in Baby?

TUESDAY, July 17 -- Men and women exposed to chemicals in the workplace may be increasing their odds of having an infant with a birth defect, two new studies suggest.In the first report, researchers linked birth defects to fathers who have certain... read more..


Scientists Say Blood Test May Help Predict Alzheimer's

WEDNESDAY, July 18 -- Researchers say they've identified an indicator, or "biomarker," in the blood that may help predict a person's risk of developing Alzheimer's disease.For their study, the investigators tested the blood of 99 women, aged 70 to... read more..

Thursday, 28 June 2012

Lung Cancer Deaths-Breast Cancer Risk-Moderate Exercise-Recurrent Strokes

Even Moderate Exercise Might Cut Breast Cancer Risk: Study

MONDAY, June 25 -- Women who exercise may cut their risk of breast cancer by as much as 30 percent, a new study suggests.Weight gain, however, may undermine the benefit of exercise, the researchers noted."Our study showed that moderate... read more..


Are Statins Less Helpful for Women?

MONDAY, June 25 -- The cholesterol-lowering drugs known as statins may be less effective for preventing death and recurrent strokes in women than in men, a new study suggests.A review of 11 trials found that statins such as Lipitor and Crestor... read more..


Lung Cancer Deaths Rise Among 'Boomer' Women in South

TUESDAY, June 26 -- Although the overall lung cancer rate in the United States has been declining in recent years, new research shows a troubling increase in lung cancer deaths among baby boomer women living in some southern and Midwestern... read more..

Sunday, 10 June 2012

Breast Cancer-Roche Holding

FDA Approves Roche Breast Cancer Drug

The FDA approved a new drug to treat women with advanced cases of a specific type of breast cancer. Perjeta, was developed by Roche Holding's Genentech unit to treat women whose breast cancer tests positive for protein called HER2 and has spread beyond the breast. (Source: WSJ.com: Health) read more..

Wednesday, 6 June 2012

Early Stage Breast Cancer-Surgical Mesh Products-Pelvic Discomfort-Online Edition

Blood Tests Might Help Guide Breast Cancer Care

TUESDAY, June 5 -- A simple blood test may help gauge prognosis and tailor treatments for women who have been diagnosed with early stage breast cancer.The test, described in the June 6 online edition of The Lancet Oncology, measures how many tumor... read more..


Side Effect Of Cortal Aspirin

i just want to ask if what are the possible side effect of cortal sapirin if taken by a pregnant women.? - Filed in Aspirin - 2 Replies read more..


J&J to Stop Selling Surgical Mesh

J&J is stopping sales of surgical mesh products that aimed to relieve the intense pelvic discomfort of thousands of women, but resulted in numerous reports of injury and several deaths. (Source: WSJ.com: Health)MedWorm Sponsor Message: Please have a look at this new site driven by MedWorm: The Breast Cancer Daily read more..

Tuesday, 5 June 2012

Experimental Cancer Drug-Duke Cancer Institute-Conventional Therapy-Disease Progression

Roche Breast-Cancer Treatment Advances

A study involving an experimental cancer drug being developed by Roche showed it delayed disease progression in women with a specific type of breast cancer compared with conventional therapy. (Source: WSJ.com: Health) read more..


Duke docs deploy 'smart bomb' on cancer

Doctors at the Duke Cancer Institute in Durham have dropped what's being called a "smart bomb" on breast cancer. Which means a drug delivered a toxic payload aimed at tumor cells while healthy cells were not targeted. A test involving nearly 1,000 women was conducted using the experimental technique, and the "bomb" extended their lives without the cancer getting worse. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors read more..


Roche Breast-Cancer Drug Advances

A study involving an experimental cancer drug being developed by Roche showed it delayed disease progression in women with a specific type of breast cancer compared with conventional therapy. (Source: WSJ.com: Health) read more..

Monday, 4 June 2012

Health Connections-Corporate Blog-Search Result-Breast Cancer-Drug Product

AZ Posts 'Reminder Drug Ad' to Its Corporate Blog

Last week I reported that AstraZeneca (AZ) posted an ad for CRESTOR on its "AZ Health Connections" corporate blog (see "AstraZeneca's Timely CRESTOR Branded Blog Post: Did It Violate Its Own Policy?"). The post included the indication for CRESTOR and also the "Important Safety Information" (ISI) that is required by the FDA whenever a drug company talks about a brand and its approved indication.
I wrote about that only because it was the first time -- to my knowledge -- that a pharma corporate blog promoted a branded product and I wondered if such posts violated AZ's own posting policies (turns out that it may or may not depending upon what you mean by "may" -- see the post for details).
Today, I noticed an AZ Health Connections blog post that talked about another AZ drug - ARIMIDEX, which is approved for "adjuvant treatment (treatment following surgery with or without radiation) of postmenopausal women with hormone receptor-positive early breast cancer."
This time, however, the post (find it here; see screen capture above) did NOT mention the approved indication. It is, by FDA definition, a "reminder ad." According to the Pharma Marketing Network Glossary:
Reminder advertisements are identified as an exemption to the advertisement regulations, including provisions to provide a brief summary. Reminder advertisements " . . . call attention to the name of the drug product but do not include indications or dosage recommendations for use of the drug product. . . . and, optionally, information . . . containing no representation or suggestion relating to the advertised drug product." Reminder advertisements cannot make a representation about the product or suggest a use for the product.The AZ Health Connections post does "call attention to the name of the drug," but it also directs readers to ARIMIDEX Direct, which is a program that "allows eligible patients to receive ARIMIDEX delivered to their homes for $40 a month, including shipping and handling." Sounds like a good deal, although I did not investigate what the eligibility requirements were.
AZ deserves credit for reaching out to the online community to learn more about how it can make its drugs more accessible. Recall that AZ was the first pharma company to host a Twitter chat "to raise awareness about helping patients save money through prescription savings programs" (see "OMG! AstraZeneca Hosts Twitter Chat & World Does NOT End!").
PhRMA "forbids" Reminder Ads, But Not on Internet!
AZ's post raises some interesting questions regarding the promotion of Rx drugs on the Internet that neither the FDA nor the pharma industry has addressed. For example, PhRMA's "Guiding Principles for Direct-to-Consumer Advertising" (here) prohibit reminder ads on TV but NOT on the Internet:
Principle #10: "DTC television advertising that identifies a product by name should clearly state the health conditions for which the medicine is approved and the major risks associated with the medicine being advertised." [Alos see "Reminder Ads - Pharma's Dodo?"]AZ, I believe, is a signatory to these voluntary guidelines. Since these guidelines only apply to TV advertising, AZ is not in violation. It's still the "wild west" on the Internet with regard to reminder ads; i.e., It's perfectly fine to run "reminder ads" on the Internet. This is usually the case when pharma companies buy Adwords (paid search ads) from Google, especially after the FDA came down on Adwords that included the indication with the brand name.
Another interesting issue is how pharma companies can manipulate "natural" (aka "organic") Google search results to display what is essentially a branded product ad that includes the brand name and indication, but no ISI.
Search Google for "arimidex" as I just did and you will find this:
The #4 (or #3, depending on how you count) search result leads you to the home page of the www.arimidex.com Web site. Note that the search result looks like an read more..

Tuesday, 29 May 2012

Hormone Replacement Therapy-Risk For Breast Cancer-Breast Cancer Risk-Danish Researchers

HRT Update: Therapy May Reduce Fractures, Boost Some Risks

MONDAY, May 28 -- Updated evidence on hormone replacement therapy for menopausal women presents good news for those at risk of osteoporosis, but a mixed bag of results regarding breast cancer and other chronic diseases.While estrogen-only and... read more..


Night Shift Might Boost Women's Breast Cancer Risk: Study

MONDAY, May 28 -- Women who work the night shift more than twice a week might be increasing their risk for breast cancer, Danish researchers find.Moreover, the risk appears to be cumulative and highest among women who describe themselves as... read more..

Thursday, 24 May 2012

Celldex Therapeutics-Breast Cancer Drug-Cosmetic Treatment-Dynamic Results

Celldex Therapeutics Breast Cancer Drug Shows Strong Results, But Only In Some Patients

An experimental breast cancer drug being developed by tiny Celldex Therapeutics of Needham., Mass., appeared to show a potent tumor-shrinking effect in four women who had both an especially hard-to-treat form of breast cancer and whose tumors had high levels of the protein targeted by the drug. But the results of the overall study in 122 patients were less impressive. (Source: Forbes.com Healthcare News) read more..


Dermataloge, Now Offering the Latest Photodynamic Cosmetic Treatment,...

Dermataloge is thrilled to be offering Allumera as the latest photodynamic cosmetic treatment that produces dynamic results for timeless skin and offers a new way for women & men to look their...(PRWeb May 23, 2012)Read the full story at http://www.prweb.com/releases/2012/5/prweb9530797.htm (Source: PRWeb: Medical Pharmaceuticals) read more..


Celldex Therapeutics Breast Cancer Drug Shows Strong Results In Some Patients

The drug helps 36% of women with triple negative breast cancer. The problem is that's only 4 women in a 121 patient trial. (Source: Forbes.com Healthcare News) read more..

Memorial Sloan-Kettering Cancer Center,-American Society Of Clinical Oncology-Initial Chemotherapy

Tesetaxel Results as Initial Chemotherapy for Women With Recurrent Breast Cancer to be Highlighted at ASCO

BERKELEY HEIGHTS, N.J., May 22, 2012 (GLOBE NEWSWIRE) -- Genta Incorporated (GNTA) today announced results from the Company's Phase 2 clinical trial using tesetaxel as initial, single-agent chemotherapy in women with advanced breast cancer. The data will be formally presented at the upcoming annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago, IL. Tesetaxel is the leading oral taxane in clinical development. The trial is lead by Memorial Sloan-Kettering Cancer Center, New York, NY, in collaboration with three other U.S. centers. (Source: Medical News (via PRIMEZONE)) read more..

Saturday, 19 May 2012

Breast Cancer In Women-Anderson Cancer Center-Breast Cancer Vaccine-Houston Chronicle

New M.D. Anderson breast cancer vaccine shows promise

Researchers at Houston-based M.D. Anderson Cancer Center reported promising results from an experimental new breast cancer vaccine.The vaccine, one of many now in testing, significantly decreased the recurrence rate of breast cancer in women who had been treated for a common tumor type, according to a study led by The University of Texas M.D. Anderson Cancer Center, the Houston Chronicle reports.The new vaccine triggers the patient's immunity against a tumor protein, known as HER2, present to... (Source: bizjournals.com Health Care:Pharmaceuticals headlines) read more..

Thursday, 17 May 2012

Hormone Replacement Therapies-Estrogen Treatments-Brandon, Manitoba-Hormone Therapy

Pfizer making deep cuts at estrogen extraction plant

Pfizer ($PFE), which faces thousands of lawsuits over hormone replacement therapies, will cut about 40% of the workforce at a Canadian plant where one of them is made.The company says that by the end of next year it will eliminate 50 of 130 jobs at a plant in Brandon, Manitoba, where it processes conjugated estrogen from pregnant mares' urine (PMU), reports the Alberta Farmer Express. It uses the product to manufacture Premarin, a hormone replacement treatment originally developed by Wyeth, which Pfizer acquired in 2009.Pfizer told the publication that it must always be looking for "efficiencies and cost reductions by using our resources and technology more effectively." It says the restructuring will not affect its network of about 25 horse ranchers in Manitoba and Saskatchewan, from which it buys the raw PMU.According to Pfizer's website, Premarin is shipped globally and accounts for more than two-thirds of all estrogen prescriptions in the U.S. It says more Premarin is exported from Canada "than any other single pharmaceutical product." It doesn't mention the 10,000 lawsuits it has been fighting by women who claim that estrogen treatments were tied to their breast cancer.The company in December said it had settled about 5,000 of 10,000 lawsuits brought on behalf of women who had taken its hormone therapy drugs Premarin, Provera and Prempro. It said in a financial filing that it had set aside about $840 million to help settle claims. That disclosure came on the heels of a settlement it reached with three women who had been awarded more than $70 million from a jury who agreed that Pfizer's estrogen treatments contributed to their getting breast cancer.The Brandon plant was built in the 1960s and Pfizer inherited it as part of its 2009  acquisition of Wyeth. The Express says Wyeth reduced its network of PMU suppliers by half about 10 years ago after health studies identified the cancer risks associated with estrogen therapy and demand for the drugs fell off.- read the Alberta Farmer Express storyRelated Articles:
Pfizer settles hormone-drug suit after $72.6M jury award
For Pfizer, 5,000 lawsuits resolved, 5,000 to go read more..

Immune Responses-Cancer Vaccines-Cancer Patients

Existing drugs boost new cancer vax responses

Cancer vaccines are becoming an increasingly attractive focus of study, but there are still perils and pitfalls along the way to success. Two recent studies have looked at ways to get around these, focusing on experimental cancer vaccines boosted by existing drugs.One of the issues that cancer vaccines face is that tumors can hide from the immune system, helped by the regulatory T cells or Tregs that normally turn off the immune system once it has finished fighting infection. These white blood cells have been co-opted by cancers to protect them from the normal immune response, also cutting the effectiveness of cancer vaccines that are designed to boost the immune responses against the tumors. Researchers at the University of Pennsylvania are looking at using daclizumab (Zenapax)--a monoclonal antibody used to prevent transplant rejection--to target the Tregs and convert them into normal T cells, and to therefore restore the immune response against the cancers.Ten women with metastatic breast cancer were treated with daclizumab and an experimental cancer vaccine developed at the university. Their Tregs converted to T cells, lasting for two months; the tumors in 6 patients stopped growing, and they survived around 30% longer than the women who had the cancer vaccine alone. The results were published in Science Translational Medicine. "Although we tested our approach in patients with breast cancer, we know that Tregs can block the immune response against most human cancers," says senior author Robert H. Vonderheide. "Drugs like daclizumab might be useful for most cancer patients, especially those receiving other types of immune therapy."This approach could work in other cancers, but this was a very small trial in patients with advanced disease, and more studies are needed--the team is planning a study in summer 2012 with the vaccine and another similar drug, as daclizumab is not currently available from its manufacturer.And in another story, adding the hormonal therapy letrozole to Oncothyreon's ($ONTY) Stimuvax lung cancer vaccine improved the responses in mice. Stimuvax is in Phase III trials, and results aren't expected until 2013.- read the press release about daclizumab
- see the abstract from Science Translational Medicine
- check out the press release about letrozole
- see the abstract from Clinical Cancer ResearchRelated Articles:
MUC1 cancer vaccine starts in the clinic
Antigen Express vaccine cuts breast cancer recurrence
Oncothyreon shares routed as Stimuvax PhIII trial soldiers on read more..

Thursday, 10 May 2012

University Of Maryland School Of Medicine-University Of Maryland Medical School

University of Maryland medical school wins $240K grant for breast cancer screening

The University of Maryland School of Medicine said Tuesday it has received a $240,000 grant from the Avon Foundation to help conduct breast cancer screenings to underinsured women living in Baltimore City.The school’s Baltimore City Breast Cancer Program program provides screenings for low-income women. Nearly 9,000 free clinical breast exams and 10,000 mammograms have been conducted under the program since it was founded in 2001. Of the 27,000 women screened, 101 have been diagnosed with breast... (Source: bizjournals.com Health Care:Pharmaceuticals headlines)MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors read more..

Sunday, 6 May 2012

Baron And Budd-American Women-Breast Cancer-Yasmin

Men's Breast Cancer Often More Deadly, Study Suggests

FRIDAY, May 4 -- Breast cancer in men is much less common than it is in women, but it may be more deadly, new research suggests."Men with breast cancer don't do as well as women with breast cancer, and there are opportunities to improve that,"... read more..


More College-Educated Women Having Children

FRIDAY, May 4 -- An increasing number of college-educated American women in their late 30s and 40s are having children, a new study shows.The findings may represent a turnaround from previous decades, when the trend was for college-educated women... read more..


Baron and Budd Seeks to Help Women Harmed by YAZ, Yasmin, Beyaz and Ocella

Baron and Budd Seeks to Help Women Harmed by YAZ, Yasmin, Beyaz and Ocella
Baron and Budd, a national law firm dedicated to Pro...
Baron & Budd P.C. read more..

Friday, 4 May 2012

Breast Cancer Screening-Menopausal Hot Flashes-Postmenopausal Women-Genetic Differences

Many Breast Cancer Patients in Their 40s Aren't 'High-Risk': Study

THURSDAY, May 3 -- More than half of women in their 40s diagnosed with breast cancer after a routine mammogram had no family history of the disease, finds a new study that may add to the debate over the timing of breast cancer screening.The... read more..


Hot Flashes More Likely for Certain Smokers, Study Says

THURSDAY, May 3 -- Women smokers with certain gene variants are at increased risk for menopausal hot flashes compared to smokers without these genetic differences, a new study says.An analysis of data from nearly 300 late reproductive-age women... read more..


New Findings of Daily Consumption of Soy Isoflavones and Cacao-Flavonoids in Diabetes Type 2 Patients

ZURICH, May 4, 2012 /PRNewswire/ --?A new, one-year, double-blind controlled clinical study shows that cacao-flavonoids and soy isoflavones can significantly improve biomarkers of CVD risk in postmenopausal women with type 2 diabetes[1].The trial, conducted by Peter J.... read more..